Drug interactions
Aluminum hydroxide + Chenodeoxycholic acid
Severity: Moderate
Aluminum hydroxide and Chenodeoxycholic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminium-containing antacids can adsorb bile acids in the gut. This reduces absorption of chenodeoxycholic acid and may weaken its therapeutic effect.
What this interaction means in plain words
Aluminum hydroxide and Chenodeoxycholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Chenodeoxycholic acid belongs to Gastrointestinal Tract.
Why it happens
Adsorption of bile acid by aluminium hydroxide in the intestinal lumen reduces absorption.
What to do
Separate the doses by at least 2 hours. Monitor clinical or biochemical response if concomitant use continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Chenodeoxycholic acid?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Chenodeoxycholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminium-containing antacids can adsorb bile acids in the gut. This reduces absorption of chenodeoxycholic acid and may weaken its therapeutic effect.
How serious is the interaction between Aluminum hydroxide and Chenodeoxycholic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the doses by at least 2 hours. Monitor clinical or biochemical response if concomitant use continues.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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