Drug interactions
Aluminum hydroxide + Cholecalciferol
Severity: Moderate
Aluminum hydroxide and Cholecalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal absorption of aluminum, and chronic use of aluminum-containing antacids can lead to aluminum accumulation. This is most important in renal impairment, where aluminum toxicity can cause bone disease and neurotoxicity.
What this interaction means in plain words
Aluminum hydroxide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.
Why it happens
Vitamin D enhances gastrointestinal aluminum absorption, and aluminum is poorly excreted in renal failure.
What to do
Avoid long-term aluminum antacids in patients taking vitamin D, particularly with renal impairment; use a non-aluminum alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Cholecalciferol?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal absorption of aluminum, and chronic use of aluminum-containing antacids can lead to aluminum accumulation. This is most important in renal impairment, where aluminum toxicity can cause bone disease and neurotoxicity.
How serious is the interaction between Aluminum hydroxide and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term aluminum antacids in patients taking vitamin D, particularly with renal impairment; use a non-aluminum alternative.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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