Drug interactions
Aluminum hydroxide + Cyclosporin
Severity: Moderate
Aluminum hydroxide and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aluminum hydroxide may reduce cyclosporine absorption, potentially lowering blood levels and weakening immunosuppression. This matters in transplant patients where subtherapeutic levels risk rejection.
What this interaction means in plain words
Aluminum hydroxide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cyclosporin belongs to Miscellaneous.
Why it happens
Binding or adsorption of cyclosporine in the gut and altered gastric conditions reduce its absorption.
What to do
Separate doses by at least 2 hours and monitor cyclosporine trough concentrations when antacid use is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Cyclosporin?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aluminum hydroxide may reduce cyclosporine absorption, potentially lowering blood levels and weakening immunosuppression. This matters in transplant patients where subtherapeutic levels risk rejection.
How serious is the interaction between Aluminum hydroxide and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor cyclosporine trough concentrations when antacid use is started or stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren. The full list is on the Cyclosporin page.
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