Drug interactions
Aluminum hydroxide + Dabrafenib
Severity: Moderate
Aluminum hydroxide and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raised gastric pH from antacids may decrease dabrafenib dissolution and absorption. The clinical impact on efficacy is uncertain.
What this interaction means in plain words
Aluminum hydroxide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Dabrafenib belongs to Oncology.
Why it happens
Higher gastric pH reduces dabrafenib solubility and bioavailability.
What to do
Separate antacid from dabrafenib by at least 2 hours and monitor tumour response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Dabrafenib
- Abiraterone + Dabrafenib Major
Frequently asked questions
Can I take Aluminum hydroxide with Dabrafenib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Raised gastric pH from antacids may decrease dabrafenib dissolution and absorption. The clinical impact on efficacy is uncertain.
How serious is the interaction between Aluminum hydroxide and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate antacid from dabrafenib by at least 2 hours and monitor tumour response.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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