Drug interactions
Aluminum hydroxide + Deferiprone
Severity: Moderate
Aluminum hydroxide and Deferiprone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone chelates polyvalent cations such as aluminum, so taking them together can reduce its absorption and effect. Iron-chelation efficacy may be reduced.
What this interaction means in plain words
Aluminum hydroxide and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Deferiprone belongs to Miscellaneous.
Why it happens
Deferiprone binds aluminum in the gut, forming complexes that reduce absorption.
What to do
Separate deferiprone from aluminum-containing antacids by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Deferiprone
Frequently asked questions
Can I take Aluminum hydroxide with Deferiprone?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone chelates polyvalent cations such as aluminum, so taking them together can reduce its absorption and effect. Iron-chelation efficacy may be reduced.
How serious is the interaction between Aluminum hydroxide and Deferiprone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate deferiprone from aluminum-containing antacids by at least 4 hours.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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