Drug interactions
Aluminum hydroxide + Demeclocycline
Severity: Moderate
Aluminum hydroxide and Demeclocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum binds tetracyclines in the gut and forms poorly absorbed complexes. Demeclocycline levels may fall, causing therapeutic failure.
What this interaction means in plain words
Aluminum hydroxide and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of demeclocycline by aluminum ions reduces gastrointestinal absorption.
What to do
Take demeclocycline at least 2 hours before or 4 hours after aluminum hydroxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Demeclocycline?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum binds tetracyclines in the gut and forms poorly absorbed complexes. Demeclocycline levels may fall, causing therapeutic failure.
How serious is the interaction between Aluminum hydroxide and Demeclocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take demeclocycline at least 2 hours before or 4 hours after aluminum hydroxide.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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