Drug interactions
Aluminum hydroxide + Dextroamphetamine
Severity: Minor
Aluminum hydroxide and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids that alkalinize urine are described as reducing amphetamine renal clearance, but aluminum hydroxide has little effect on urinary pH and no meaningful interaction is established. Any effect would be minimal.
What this interaction means in plain words
Aluminum hydroxide and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Alkaline urine increases amphetamine reabsorption, but aluminum hydroxide does not substantially alkalinize urine.
What to do
No action is generally needed. Be aware if the patient also takes strongly alkalinizing agents such as sodium bicarbonate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Dextroamphetamine?
MediHelp rates the interaction as minor. Aluminum hydroxide and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids that alkalinize urine are described as reducing amphetamine renal clearance, but aluminum hydroxide has little effect on urinary pH and no meaningful interaction is established. Any effect would be minimal.
How serious is the interaction between Aluminum hydroxide and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Be aware if the patient also takes strongly alkalinizing agents such as sodium bicarbonate.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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