Drug interactions
Aluminum hydroxide + Ergocalciferol
Severity: Moderate
Aluminum hydroxide and Ergocalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal absorption of aluminum from aluminum-containing antacids. Chronic use, especially in renal impairment, can cause aluminum accumulation and toxicity affecting bone and the brain.
What this interaction means in plain words
Aluminum hydroxide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Ergocalciferol belongs to Musculoskeletal.
Why it happens
Vitamin D enhances intestinal absorption of aluminum, and renal impairment limits its excretion.
What to do
Avoid long-term use of aluminum antacids in patients taking vitamin D, particularly with renal impairment. Use a non-aluminum alternative such as calcium carbonate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Ergocalciferol?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal absorption of aluminum from aluminum-containing antacids. Chronic use, especially in renal impairment, can cause aluminum accumulation and toxicity affecting bone and the brain.
How serious is the interaction between Aluminum hydroxide and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use of aluminum antacids in patients taking vitamin D, particularly with renal impairment. Use a non-aluminum alternative such as calcium carbonate.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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