Drug interactions
Aluminum hydroxide + Glibenclamide
Severity: Minor
Aluminum hydroxide and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may increase glyburide absorption, potentially enhancing glucose-lowering. Significant hypoglycemia is uncommon with aluminum hydroxide.
What this interaction means in plain words
Aluminum hydroxide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Glibenclamide belongs to Endocrine.
Why it happens
Altered gastric pH and motility may enhance glyburide absorption.
What to do
No routine change needed. Monitor blood glucose when antacid use is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Aluminum hydroxide with Glibenclamide?
MediHelp rates the interaction as minor. Aluminum hydroxide and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids may increase glyburide absorption, potentially enhancing glucose-lowering. Significant hypoglycemia is uncommon with aluminum hydroxide.
How serious is the interaction between Aluminum hydroxide and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Monitor blood glucose when antacid use is started or stopped.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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