Drug interactions
Aluminum hydroxide + Ibandronate
Severity: Moderate
Aluminum hydroxide and Ibandronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral ibandronate absorption is greatly reduced by cation-containing products such as aluminum antacids. This may lead to loss of bone-protective effect.
What this interaction means in plain words
Aluminum hydroxide and Ibandronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Ibandronate belongs to Musculoskeletal.
Why it happens
Aluminum forms insoluble complexes with ibandronate in the gut, preventing absorption.
What to do
Take ibandronate after an overnight fast with plain water and wait at least 60 minutes before antacids, food or other medications.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Ibandronate?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Ibandronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral ibandronate absorption is greatly reduced by cation-containing products such as aluminum antacids. This may lead to loss of bone-protective effect.
How serious is the interaction between Aluminum hydroxide and Ibandronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take ibandronate after an overnight fast with plain water and wait at least 60 minutes before antacids, food or other medications.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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