Drug interactions
Aluminum hydroxide + Indinavir
Severity: Moderate
Aluminum hydroxide and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir needs gastric acid for absorption, and antacids raise pH. Lower indinavir levels may reduce antiviral efficacy.
What this interaction means in plain words
Aluminum hydroxide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces indinavir dissolution and absorption.
What to do
Separate indinavir and the antacid by at least 1 hour and monitor virologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Indinavir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir needs gastric acid for absorption, and antacids raise pH. Lower indinavir levels may reduce antiviral efficacy.
How serious is the interaction between Aluminum hydroxide and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate indinavir and the antacid by at least 1 hour and monitor virologic response.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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