Drug interactions
Aluminum hydroxide + Infigratinib
Severity: Moderate
Aluminum hydroxide and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib absorption depends on gastric acidity, so antacids may reduce its exposure and antitumor effect.
What this interaction means in plain words
Aluminum hydroxide and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of infigratinib.
What to do
Take infigratinib at least 2 hours before or 2 hours after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Infigratinib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib absorption depends on gastric acidity, so antacids may reduce its exposure and antitumor effect.
How serious is the interaction between Aluminum hydroxide and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take infigratinib at least 2 hours before or 2 hours after the antacid.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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