Drug interactions
Aluminum hydroxide + Isoniazid
Severity: Moderate
Aluminum hydroxide and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum-containing antacids can reduce isoniazid absorption, potentially lowering serum levels. This may compromise antituberculous efficacy.
What this interaction means in plain words
Aluminum hydroxide and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Isoniazid belongs to Anti Bacterial.
Why it happens
Aluminum hydroxide reduces gastrointestinal absorption of isoniazid, likely via adsorption or altered gastric conditions.
What to do
Give isoniazid on an empty stomach at least 1 to 2 hours before the antacid. Monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Isoniazid?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum-containing antacids can reduce isoniazid absorption, potentially lowering serum levels. This may compromise antituberculous efficacy.
How serious is the interaction between Aluminum hydroxide and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give isoniazid on an empty stomach at least 1 to 2 hours before the antacid. Monitor treatment response.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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