Drug interactions
Aluminum hydroxide + Lanthanum carbonate
Severity: Moderate
Aluminum hydroxide and Lanthanum carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing metal cations can bind lanthanum in the gut and alter its phosphate-binding action. Aluminum exposure in kidney disease also adds concern, as both agents are used in dialysis patients.
What this interaction means in plain words
Aluminum hydroxide and Lanthanum carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Lanthanum carbonate belongs to Miscellaneous.
Why it happens
Cation binding in the gastrointestinal tract interferes with lanthanum's activity and absorption.
What to do
Give the antacid at least 2 hours before or after lanthanum. Monitor serum phosphate and aluminum burden in renal patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Lanthanum carbonate?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Lanthanum carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing metal cations can bind lanthanum in the gut and alter its phosphate-binding action. Aluminum exposure in kidney disease also adds concern, as both agents are used in dialysis patients.
How serious is the interaction between Aluminum hydroxide and Lanthanum carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or after lanthanum. Monitor serum phosphate and aluminum burden in renal patients.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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