Drug interactions
Aluminum hydroxide + Ledipasvir / sofosbuvir
Severity: Moderate
Aluminum hydroxide and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir dissolves less well as gastric pH rises, so antacids can reduce its absorption. Lower exposure may reduce the chance of hepatitis C cure.
What this interaction means in plain words
Aluminum hydroxide and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH decreases the solubility and absorption of ledipasvir.
What to do
Separate the antacid and ledipasvir/sofosbuvir by 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Aluminum hydroxide and Ledipasvir / sofosbuvir interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir dissolves less well as gastric pH rises, so antacids can reduce its absorption. Lower exposure may reduce the chance of hepatitis C cure.
How serious is the interaction between Aluminum hydroxide and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid and ledipasvir/sofosbuvir by 4 hours.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
