Drug interactions
Aluminum hydroxide + Levoketoconazole
Severity: Moderate
Aluminum hydroxide and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole requires gastric acid for dissolution, and antacids raise gastric pH. Absorption may fall and cortisol control may be lost.
What this interaction means in plain words
Aluminum hydroxide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Levoketoconazole belongs to Endocrine.
Why it happens
Elevated gastric pH reduces levoketoconazole dissolution and absorption.
What to do
Take the antacid at least 2 hours after levoketoconazole, and monitor cortisol control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Levoketoconazole?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole requires gastric acid for dissolution, and antacids raise gastric pH. Absorption may fall and cortisol control may be lost.
How serious is the interaction between Aluminum hydroxide and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the antacid at least 2 hours after levoketoconazole, and monitor cortisol control.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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