Drug interactions
Aluminum hydroxide + Moxifloxacin
Severity: Moderate
Aluminum hydroxide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminium antacids bind oral moxifloxacin and decrease its absorption. This may result in subtherapeutic concentrations and failure of antibiotic therapy.
What this interaction means in plain words
Aluminum hydroxide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Aluminium cations chelate moxifloxacin in the gut, forming poorly absorbed complexes.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after aluminium-containing antacids, per labeling. Use a non-interacting acid suppressant if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Moxifloxacin?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminium antacids bind oral moxifloxacin and decrease its absorption. This may result in subtherapeutic concentrations and failure of antibiotic therapy.
How serious is the interaction between Aluminum hydroxide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after aluminium-containing antacids, per labeling. Use a non-interacting acid suppressant if needed.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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