Drug interactions
Aluminum hydroxide + Mycophenolate mofetil
Severity: Moderate
Aluminum hydroxide and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing aluminum and magnesium hydroxide reduce absorption of mycophenolate mofetil. This may lower mycophenolic acid exposure and weaken immunosuppression.
What this interaction means in plain words
Aluminum hydroxide and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Reduced gastrointestinal absorption through cation binding and raised gastric pH.
What to do
Separate dosing by at least 2 hours and avoid concurrent administration where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing aluminum and magnesium hydroxide reduce absorption of mycophenolate mofetil. This may lower mycophenolic acid exposure and weaken immunosuppression.
How serious is the interaction between Aluminum hydroxide and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by at least 2 hours and avoid concurrent administration where possible.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live. The full list is on the Mycophenolate mofetil page.
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