Drug interactions
Aluminum hydroxide + Neratinib
Severity: Moderate
Aluminum hydroxide and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids raise gastric pH, and neratinib dissolves less well at higher pH, so exposure may fall. This could reduce antitumor efficacy.
What this interaction means in plain words
Aluminum hydroxide and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of neratinib.
What to do
Take neratinib at least 3 hours after the antacid, or separate the doses by 3 hours in either direction per labeling. Avoid proton pump inhibitors and H2 blockers where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Neratinib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids raise gastric pH, and neratinib dissolves less well at higher pH, so exposure may fall. This could reduce antitumor efficacy.
How serious is the interaction between Aluminum hydroxide and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take neratinib at least 3 hours after the antacid, or separate the doses by 3 hours in either direction per labeling. Avoid proton pump inhibitors and H2 blockers where possible.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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