Drug interactions
Aluminum hydroxide + Pexidartinib
Severity: Moderate
Aluminum hydroxide and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Locally acting antacids can lower pexidartinib absorption, likely through effects on gastric pH. Reduced exposure could diminish efficacy.
What this interaction means in plain words
Aluminum hydroxide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Raised gastric pH reduces the solubility and absorption of pexidartinib.
What to do
Take pexidartinib at least 2 hours before or 2 hours after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Pexidartinib
Frequently asked questions
Can I take Aluminum hydroxide with Pexidartinib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Locally acting antacids can lower pexidartinib absorption, likely through effects on gastric pH. Reduced exposure could diminish efficacy.
How serious is the interaction between Aluminum hydroxide and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take pexidartinib at least 2 hours before or 2 hours after the antacid.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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