Drug interactions
Aluminum hydroxide + Polysaccharide iron
Severity: Moderate
Aluminum hydroxide and Polysaccharide iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids can lower the absorption of oral iron, including polysaccharide iron complexes. This may blunt the response to iron supplementation.
What this interaction means in plain words
Aluminum hydroxide and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH and binding in the gut reduce iron solubility and absorption.
What to do
Separate the antacid and iron by at least 2 hours. Monitor hemoglobin and ferritin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Polysaccharide iron?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Polysaccharide iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids can lower the absorption of oral iron, including polysaccharide iron complexes. This may blunt the response to iron supplementation.
How serious is the interaction between Aluminum hydroxide and Polysaccharide iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid and iron by at least 2 hours. Monitor hemoglobin and ferritin.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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