Drug interactions
Aluminum hydroxide + Riociguat
Severity: Moderate
Aluminum hydroxide and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids reduce riociguat absorption, lowering its exposure. This may reduce its effect in pulmonary hypertension.
What this interaction means in plain words
Aluminum hydroxide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Riociguat belongs to Cardiovascular.
Why it happens
Higher gastric pH and gut binding reduce riociguat dissolution and absorption.
What to do
Take riociguat at least 1 hour before or after the antacid. Monitor symptoms and exercise tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Riociguat?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids reduce riociguat absorption, lowering its exposure. This may reduce its effect in pulmonary hypertension.
How serious is the interaction between Aluminum hydroxide and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take riociguat at least 1 hour before or after the antacid. Monitor symptoms and exercise tolerance.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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