Drug interactions
Aluminum hydroxide + Risedronate
Severity: Moderate
Aluminum hydroxide and Risedronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum binds risedronate in the gut and markedly reduces its absorption, which is already low. This can undermine the bone-protective effect of treatment.
What this interaction means in plain words
Aluminum hydroxide and Risedronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Risedronate belongs to Musculoskeletal.
Why it happens
Aluminum chelates risedronate in the gastrointestinal lumen, forming poorly absorbed complexes.
What to do
Take risedronate at least 30 minutes before any aluminum antacid, following labeling for fasting administration. For delayed-release forms, follow the label timing, and avoid taking them together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Risedronate?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Risedronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum binds risedronate in the gut and markedly reduces its absorption, which is already low. This can undermine the bone-protective effect of treatment.
How serious is the interaction between Aluminum hydroxide and Risedronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take risedronate at least 30 minutes before any aluminum antacid, following labeling for fasting administration. For delayed-release forms, follow the label timing, and avoid taking them together.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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