Drug interactions
Aluminum hydroxide + Sotorasib
Severity: Moderate
Aluminum hydroxide and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility depends on gastric acidity, so antacids can lower its exposure and may reduce anticancer efficacy.
What this interaction means in plain words
Aluminum hydroxide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of sotorasib.
What to do
Take sotorasib 4 hours before or 10 hours after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Sotorasib?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib solubility depends on gastric acidity, so antacids can lower its exposure and may reduce anticancer efficacy.
How serious is the interaction between Aluminum hydroxide and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take sotorasib 4 hours before or 10 hours after the antacid.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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