Drug interactions
Aluminum hydroxide + Sparsentan
Severity: Moderate
Aluminum hydroxide and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may reduce sparsentan exposure by raising gastric pH, which may reduce its antiproteinuric effect.
What this interaction means in plain words
Aluminum hydroxide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Increased gastric pH lowers the pH-dependent solubility and absorption of sparsentan.
What to do
Take sparsentan 2 hours before or after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Sparsentan?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids may reduce sparsentan exposure by raising gastric pH, which may reduce its antiproteinuric effect.
How serious is the interaction between Aluminum hydroxide and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take sparsentan 2 hours before or after the antacid.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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