Drug interactions
Aluminum hydroxide + Ursodiol
Severity: Moderate
Aluminum hydroxide and Ursodiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aluminum-based antacids can adsorb bile acids in the gut. This may reduce ursodiol absorption and its benefit in gallstone or cholestatic disease.
What this interaction means in plain words
Aluminum hydroxide and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Ursodiol belongs to Gastrointestinal Tract.
Why it happens
Aluminum hydroxide binds bile acids in the intestine, reducing ursodiol absorption.
What to do
Avoid aluminum-containing antacids with ursodiol where possible. If needed, separate doses by at least 2 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Ursodiol?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Ursodiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum-based antacids can adsorb bile acids in the gut. This may reduce ursodiol absorption and its benefit in gallstone or cholestatic disease.
How serious is the interaction between Aluminum hydroxide and Ursodiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid aluminum-containing antacids with ursodiol where possible. If needed, separate doses by at least 2 hours.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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