Drug interactions
Aluminum hydroxide + Vismodegib
Severity: Minor
Aluminum hydroxide and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib solubility depends on gastric pH, and antacids that raise pH may change its absorption. The clinical effect on efficacy is not established.
What this interaction means in plain words
Aluminum hydroxide and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aluminum hydroxide belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH may alter vismodegib solubility and bioavailability.
What to do
Label guidance allows co-use of antacids. Separate doses by about 2 hours if concerned about reduced efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Vismodegib?
MediHelp rates the interaction as minor. Aluminum hydroxide and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vismodegib solubility depends on gastric pH, and antacids that raise pH may change its absorption. The clinical effect on efficacy is not established.
How serious is the interaction between Aluminum hydroxide and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Label guidance allows co-use of antacids. Separate doses by about 2 hours if concerned about reduced efficacy.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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