Drug interactions
Amantadine + Bupropion
Severity: Moderate
Amantadine and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance dopaminergic activity and can cause neuropsychiatric effects. Together they may increase the risk of agitation, confusion, hallucinations, and possibly seizures. Bupropion also lowers the seizure threshold.
What this interaction means in plain words
Amantadine and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Bupropion belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic dopaminergic and CNS stimulant effects, with bupropion lowering seizure threshold.
What to do
Start with low doses and titrate slowly, monitoring for agitation, confusion, hallucinations, and seizures. Reduce or stop one agent if neuropsychiatric effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Bupropion?
MediHelp rates the interaction as moderate. Amantadine and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance dopaminergic activity and can cause neuropsychiatric effects. Together they may increase the risk of agitation, confusion, hallucinations, and possibly seizures. Bupropion also lowers the seizure threshold.
How serious is the interaction between Amantadine and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, monitoring for agitation, confusion, hallucinations, and seizures. Reduce or stop one agent if neuropsychiatric effects emerge.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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