Drug interactions
Amantadine + Diphenoxylate-atropine
Severity: Moderate
Amantadine and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine in the combination and amantadine both have anticholinergic effects, so together they may cause dry mouth, constipation, urinary retention, confusion and hallucinations. Older patients are most at risk.
What this interaction means in plain words
Amantadine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive antimuscarinic activity.
What to do
Monitor for anticholinergic effects, particularly confusion and urinary retention, and reduce or stop the antidiarrheal if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Amantadine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine in the combination and amantadine both have anticholinergic effects, so together they may cause dry mouth, constipation, urinary retention, confusion and hallucinations. Older patients are most at risk.
How serious is the interaction between Amantadine and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly confusion and urinary retention, and reduce or stop the antidiarrheal if they occur.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Alfentanil, Alvimopan. The full list is on the Diphenoxylate-atropine page.
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