Drug interactions
Amantadine + Lurasidone
Severity: Moderate
Amantadine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors and can counteract the dopaminergic antiparkinsonian effect of amantadine, worsening parkinsonian symptoms. Conversely, amantadine's dopaminergic action may in theory aggravate psychosis.
What this interaction means in plain words
Amantadine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade and dopaminergic enhancement.
What to do
Monitor motor symptoms and psychiatric status when combining. Use the lowest effective lurasidone dose, or consider a lower-D2-affinity antipsychotic in parkinsonian patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Lurasidone?
MediHelp rates the interaction as moderate. Amantadine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors and can counteract the dopaminergic antiparkinsonian effect of amantadine, worsening parkinsonian symptoms. Conversely, amantadine's dopaminergic action may in theory aggravate psychosis.
How serious is the interaction between Amantadine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and psychiatric status when combining. Use the lowest effective lurasidone dose, or consider a lower-D2-affinity antipsychotic in parkinsonian patients.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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