Drug interactions
Amantadine + Triamterene
Severity: Moderate
Amantadine and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene, often combined with hydrochlorothiazide, can reduce amantadine renal elimination and raise its levels. Reported consequences include amantadine toxicity with confusion, ataxia and myoclonus, particularly in older patients.
What this interaction means in plain words
Amantadine and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular cationic secretion reducing amantadine clearance.
What to do
Monitor for signs of amantadine toxicity and consider lowering the amantadine dose. Check renal function and consider an alternative diuretic if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Amantadine with Triamterene?
MediHelp rates the interaction as moderate. Amantadine and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene, often combined with hydrochlorothiazide, can reduce amantadine renal elimination and raise its levels. Reported consequences include amantadine toxicity with confusion, ataxia and myoclonus, particularly in older patients.
How serious is the interaction between Amantadine and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of amantadine toxicity and consider lowering the amantadine dose. Check renal function and consider an alternative diuretic if toxicity occurs.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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