Drug interactions
Amantadine + Vandetanib
Severity: Moderate
Amantadine and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits the renal uptake transporter OCT2, which helps eliminate amantadine. Amantadine exposure may therefore increase, with a risk of CNS toxicity. Vandetanib also prolongs the QT interval, and amantadine has been linked to QT effects.
What this interaction means in plain words
Amantadine and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Vandetanib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal secretion of amantadine.
What to do
Monitor for amantadine toxicity and consider a lower dose. Obtain an ECG and check electrolytes given the QT risk with vandetanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Amantadine with Vandetanib?
MediHelp rates the interaction as moderate. Amantadine and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits the renal uptake transporter OCT2, which helps eliminate amantadine. Amantadine exposure may therefore increase, with a risk of CNS toxicity. Vandetanib also prolongs the QT interval, and amantadine has been linked to QT effects.
How serious is the interaction between Amantadine and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for amantadine toxicity and consider a lower dose. Obtain an ECG and check electrolytes given the QT risk with vandetanib.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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