Drug interactions
Amantadine + Zuranolone
Severity: Moderate
Amantadine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes sedation and impaired psychomotor performance, and amantadine can cause dizziness, confusion and other CNS effects. Taken together they may increase impairment of driving ability and alertness.
What this interaction means in plain words
Amantadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS effects; zuranolone is a GABA-A positive modulator and amantadine has CNS activity.
What to do
Counsel patients about additive drowsiness and avoid driving or hazardous tasks. Consider lowering the zuranolone dose if excessive sedation or confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Amantadine with Zuranolone?
MediHelp rates the interaction as moderate. Amantadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes sedation and impaired psychomotor performance, and amantadine can cause dizziness, confusion and other CNS effects. Taken together they may increase impairment of driving ability and alertness.
How serious is the interaction between Amantadine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving or hazardous tasks. Consider lowering the zuranolone dose if excessive sedation or confusion develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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