Drug interactions
American ginseng + Sulindac
Severity: Minor
American ginseng and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
American ginseng has been reported to reduce the anticoagulant effect of warfarin and may have mild antiplatelet activity. With sulindac, the effect on bleeding risk is uncertain and supported by limited data.
What this interaction means in plain words
American ginseng and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest antiplatelet effects of ginseng additive to NSAID platelet inhibition; mechanism not well established.
What to do
No routine change needed. Advise patients to report unusual bruising or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take American ginseng with Sulindac?
MediHelp rates the interaction as minor. American ginseng and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. American ginseng has been reported to reduce the anticoagulant effect of warfarin and may have mild antiplatelet activity. With sulindac, the effect on bleeding risk is uncertain and supported by limited data.
How serious is the interaction between American ginseng and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed. Advise patients to report unusual bruising or bleeding.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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