Drug interactions
Amifampridine + Ciprofloxacin
Severity: Moderate
Amifampridine and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and fluoroquinolones such as ciprofloxacin can lower seizure threshold. Combining them may increase seizure risk, particularly in patients with epilepsy or renal impairment.
What this interaction means in plain words
Amifampridine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic lowering of the seizure threshold (GABA antagonism by fluoroquinolones plus potassium channel blockade by amifampridine).
What to do
Use an alternative antibiotic if possible. If combined, use the lowest effective amifampridine dose and monitor for neurological symptoms or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Ciprofloxacin?
MediHelp rates the interaction as moderate. Amifampridine and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and fluoroquinolones such as ciprofloxacin can lower seizure threshold. Combining them may increase seizure risk, particularly in patients with epilepsy or renal impairment.
How serious is the interaction between Amifampridine and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If combined, use the lowest effective amifampridine dose and monitor for neurological symptoms or seizures.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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