Drug interactions
ciprofloxacin + tizanidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Profound hypotension/sedation; co-use is contraindicated.
Mechanism of action
CYP1A2 inhibition → ↑ tizanidine.
Clinical management
Do not co-administer; switch muscle relaxant or antibiotic.
Drug reference
References
Frequently asked questions
Can I take ciprofloxacin with tizanidine?
The interaction is rated: Contraindicated. Profound hypotension/sedation; co-use is contraindicated.
How serious is the interaction between ciprofloxacin and tizanidine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between ciprofloxacin and tizanidine managed?
Do not co-administer; switch muscle relaxant or antibiotic.
Why do ciprofloxacin and tizanidine interact?
CYP1A2 inhibition → ↑ tizanidine.
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