Drug interactions
Amifampridine + Levofloxacin
Severity: Moderate
Amifampridine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and levofloxacin can also lower the seizure threshold. Using both together may increase the likelihood of a seizure.
What this interaction means in plain words
Amifampridine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold through separate pharmacodynamic effects.
What to do
Use the lowest effective amifampridine dose, or choose a non-quinolone antibiotic if possible. Monitor for neurological signs of seizure activity during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Levofloxacin?
MediHelp rates the interaction as moderate. Amifampridine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and levofloxacin can also lower the seizure threshold. Using both together may increase the likelihood of a seizure.
How serious is the interaction between Amifampridine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose, or choose a non-quinolone antibiotic if possible. Monitor for neurological signs of seizure activity during co-therapy.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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