Drug interactions
Amifampridine + Linezolid
Severity: Moderate
Amifampridine and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and linezolid has been associated with seizures. Combining them may further lower the seizure threshold.
What this interaction means in plain words
Amifampridine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic lowering of seizure threshold; no established pharmacokinetic mechanism.
What to do
Monitor for seizure activity and use the lowest effective amifampridine dose; consider an alternative antibiotic in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Linezolid?
MediHelp rates the interaction as moderate. Amifampridine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and linezolid has been associated with seizures. Combining them may further lower the seizure threshold.
How serious is the interaction between Amifampridine and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for seizure activity and use the lowest effective amifampridine dose; consider an alternative antibiotic in patients with seizure history.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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