Drug interactions
Amifampridine + Memantine-donepezil
Severity: Moderate
Amifampridine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance cholinergic transmission, so combined use may increase cholinergic adverse effects such as nausea, diarrhea, bradycardia and sweating. Amifampridine also lowers seizure threshold, which is a concern at higher exposure.
What this interaction means in plain words
Amifampridine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive cholinergic effects from acetylcholinesterase inhibition and enhanced acetylcholine release via potassium channel blockade.
What to do
Monitor heart rate, GI symptoms and neurologic status, and reduce the dose of either drug if cholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Memantine-donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Amifampridine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance cholinergic transmission, so combined use may increase cholinergic adverse effects such as nausea, diarrhea, bradycardia and sweating. Amifampridine also lowers seizure threshold, which is a concern at higher exposure.
How serious is the interaction between Amifampridine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, GI symptoms and neurologic status, and reduce the dose of either drug if cholinergic effects appear.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
