Drug interactions
Amiodarone + Memantine-donepezil
Severity: Major
Amiodarone and Memantine-donepezil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and amiodarone can prolong the QT interval. Combined use increases the risk of torsades de pointes, and amiodarone's bradycardic effect adds to the cholinergic slowing of heart rate from donepezil.
What this interaction means in plain words
Amiodarone and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation and bradycardia through pharmacodynamic effects.
What to do
Avoid the combination where possible. If it is necessary, obtain a baseline and follow-up ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
- Anagrelide + Memantine-donepezil Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Memantine-donepezil?
MediHelp rates the interaction as major. Amiodarone and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both donepezil and amiodarone can prolong the QT interval. Combined use increases the risk of torsades de pointes, and amiodarone's bradycardic effect adds to the cholinergic slowing of heart rate from donepezil.
How serious is the interaction between Amiodarone and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, obtain a baseline and follow-up ECG and correct potassium and magnesium.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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