Drug reference
memantine-donepezil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Alzheimer's Drugs)
Mechanism of action
Memantine: Low- to moderate-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist that binds preferentially to NMDAR-operated cation channels, Donepezil: Acetylcholinesterase inhibitor that causes an increase in concentrations of acetylcholine, which in turn enhances cholinergic neurotransmission
Common side effects
- Insomnia
- Dizziness
- Nausea
- Infection
- Accident
- Diarrhea
Known interactions (2)
- dronedarone + memantine-donepezil Contraindicated
- dextromethorphan + memantine-donepezil Moderate
Related conditions
Frequently asked questions
What drug class is memantine-donepezil?
memantine-donepezil belongs to: Central Nervous System.
How does memantine-donepezil work?
Memantine: Low- to moderate-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist that binds preferentially to NMDAR-operated cation channels, Donepezil: Acetylcholinesterase inhibitor that causes an increase in concentrations of acetylcholine, which in turn enhances cholinergic neurotransmission
What are the common side effects of memantine-donepezil?
Insomnia, Dizziness, Nausea, Infection, Accident, Diarrhea
Which drugs interact with memantine-donepezil?
dronedarone, dextromethorphan
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