Drug interactions
Amifostine + Amiodarone
Severity: Moderate
Amifostine and Amiodarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and amiodarone, particularly when given intravenously, can also lower blood pressure. Taken together, the hypotensive effects may be additive and more severe, which matters most at chemotherapeutic amifostine doses.
What this interaction means in plain words
Amifostine and Amiodarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Amiodarone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from vasodilation and negative cardiovascular effects of amiodarone combined with amifostine-induced hypotension.
What to do
Monitor blood pressure closely before and during amifostine infusion and ensure adequate hydration. If amiodarone cannot be held and the amifostine dose is at chemotherapeutic level, reassess whether amifostine should be given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifostine and Amiodarone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Amiodarone?
MediHelp rates the interaction as moderate. Amifostine and Amiodarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and amiodarone, particularly when given intravenously, can also lower blood pressure. Taken together, the hypotensive effects may be additive and more severe, which matters most at chemotherapeutic amifostine doses.
How serious is the interaction between Amifostine and Amiodarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely before and during amifostine infusion and ensure adequate hydration. If amiodarone cannot be held and the amifostine dose is at chemotherapeutic level, reassess whether amifostine should be given.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
