Drug interactions
Amifostine + Aripiprazole
Severity: Moderate
Amifostine and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and aripiprazole's alpha-1 adrenergic blockade can add to this effect. Patients may develop symptomatic hypotension or orthostasis during infusion.
What this interaction means in plain words
Amifostine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Aripiprazole belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from amifostine and the alpha-1 adrenergic antagonism of aripiprazole.
What to do
Monitor blood pressure before and during amifostine infusion, and keep the patient hydrated and supine if hypotension occurs. Antihypertensive medication is normally withheld before amifostine; consider whether aripiprazole timing needs adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Aripiprazole?
MediHelp rates the interaction as moderate. Amifostine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and aripiprazole's alpha-1 adrenergic blockade can add to this effect. Patients may develop symptomatic hypotension or orthostasis during infusion.
How serious is the interaction between Amifostine and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion, and keep the patient hydrated and supine if hypotension occurs. Antihypertensive medication is normally withheld before amifostine; consider whether aripiprazole timing needs adjustment.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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