Drug interactions
Amifostine + Nebivolol
Severity: Moderate
Amifostine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and antihypertensives such as nebivolol can make this worse. At chemotherapeutic doses of amifostine the hypotension can be significant and may force interruption of the infusion.
What this interaction means in plain words
Amifostine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Nebivolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
When amifostine is given at chemotherapy doses, consider withholding nebivolol for 24 hours beforehand if clinically feasible; if it cannot be withheld, avoid amifostine. Monitor blood pressure closely during infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Nebivolol?
MediHelp rates the interaction as moderate. Amifostine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and antihypertensives such as nebivolol can make this worse. At chemotherapeutic doses of amifostine the hypotension can be significant and may force interruption of the infusion.
How serious is the interaction between Amifostine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When amifostine is given at chemotherapy doses, consider withholding nebivolol for 24 hours beforehand if clinically feasible; if it cannot be withheld, avoid amifostine. Monitor blood pressure closely during infusion.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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