Drug interactions
Amifostine + Phentolamine
Severity: Moderate
Amifostine and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and an alpha-blocker such as phentolamine may worsen it. This is particularly relevant at chemotherapeutic amifostine doses.
What this interaction means in plain words
Amifostine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Phentolamine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Where amifostine is given at chemotherapy doses, withhold blood pressure lowering drugs for 24 hours beforehand if possible, and do not give amifostine if they cannot be withheld. Monitor blood pressure closely during infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phentolamine
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Phentolamine?
MediHelp rates the interaction as moderate. Amifostine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and an alpha-blocker such as phentolamine may worsen it. This is particularly relevant at chemotherapeutic amifostine doses.
How serious is the interaction between Amifostine and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where amifostine is given at chemotherapy doses, withhold blood pressure lowering drugs for 24 hours beforehand if possible, and do not give amifostine if they cannot be withheld. Monitor blood pressure closely during infusion.
What other medicines interact with Phentolamine?
MediHelp also lists interactions of Phentolamine with, for example, Alfuzosin, Avanafil, Doxazosin. The full list is on the Phentolamine page.
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