Drug interactions
Avanafil + Phentolamine
Severity: Major
Avanafil and Phentolamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause vasodilation, so together they may produce marked hypotension or syncope. Phentolamine is an alpha-blocker, and PDE5 inhibitors can cause symptomatic hypotension with alpha-blockers.
What this interaction means in plain words
Avanafil and Phentolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Phentolamine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and PDE5 inhibition.
What to do
Avoid combining where possible; if necessary, ensure hemodynamic stability, use the lowest avanafil dose, and monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Phentolamine
Frequently asked questions
Can I take Avanafil with Phentolamine?
MediHelp rates the interaction as major. Avanafil and Phentolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents cause vasodilation, so together they may produce marked hypotension or syncope. Phentolamine is an alpha-blocker, and PDE5 inhibitors can cause symptomatic hypotension with alpha-blockers.
How serious is the interaction between Avanafil and Phentolamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, ensure hemodynamic stability, use the lowest avanafil dose, and monitor blood pressure closely.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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