Drug interactions
Amifostine + Quetiapine
Severity: Moderate
Amifostine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, and amifostine commonly causes hypotension during infusion. Together they may cause a more pronounced fall in blood pressure.
What this interaction means in plain words
Amifostine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Quetiapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and amifostine-related hypotension.
What to do
Monitor blood pressure before and during amifostine infusion and consider holding antihypertensives as per amifostine labeling. Consider temporarily holding or adjusting quetiapine if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Quetiapine?
MediHelp rates the interaction as moderate. Amifostine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, and amifostine commonly causes hypotension during infusion. Together they may cause a more pronounced fall in blood pressure.
How serious is the interaction between Amifostine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and consider holding antihypertensives as per amifostine labeling. Consider temporarily holding or adjusting quetiapine if hypotension occurs.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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