Drug interactions
Amifostine + Secobarbital
Severity: Moderate
Amifostine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and barbiturates can also lower blood pressure. Together they may produce more pronounced hypotension.
What this interaction means in plain words
Amifostine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.
Why it happens
Additive hypotensive effects; amifostine causes vasodilation and barbiturates depress vasomotor and CNS function.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensives as per amifostine labeling and review the need for sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Secobarbital?
MediHelp rates the interaction as moderate. Amifostine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and barbiturates can also lower blood pressure. Together they may produce more pronounced hypotension.
How serious is the interaction between Amifostine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensives as per amifostine labeling and review the need for sedatives.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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