Drug interactions
Elbasvir / grazoprevir + Secobarbital
Severity: Contraindicated
Elbasvir / grazoprevir and Secobarbital: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can lower elbasvir and grazoprevir concentrations. This may lead to hepatitis C virologic failure. Labeling contraindicates strong CYP3A inducers.
What this interaction means in plain words
Elbasvir / grazoprevir and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Barbiturate-mediated CYP3A4 induction increases clearance of both antivirals.
What to do
Avoid the combination. Use a non-inducing sedative alternative during therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
- Lorlatinib + Secobarbital Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Secobarbital?
MediHelp rates the interaction as contraindicated. Elbasvir / grazoprevir and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can lower elbasvir and grazoprevir concentrations. This may lead to hepatitis C virologic failure. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Elbasvir / grazoprevir and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-inducing sedative alternative during therapy.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Secobarbital page.
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