Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Secobarbital
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Secobarbital: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybate is a potent CNS depressant, and secobarbital is a barbiturate that adds to this effect. Together they can cause profound sedation, respiratory depression, coma and death. Oxybate labeling prohibits use with sedative hypnotics.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Do not combine the two drugs. Use a non-sedating alternative to the barbiturate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Secobarbital
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
- Lorlatinib + Secobarbital Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Secobarbital?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybate is a potent CNS depressant, and secobarbital is a barbiturate that adds to this effect. Together they can cause profound sedation, respiratory depression, coma and death. Oxybate labeling prohibits use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two drugs. Use a non-sedating alternative to the barbiturate.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Doravirine, Elbasvir / grazoprevir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Secobarbital page.
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